Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING TABLET OF FAMOTIDINE

Patil Bhupendra S.*, Dr. Jain Parag, Dr. Sarode Surajj, Mr. Sathe  Bhushankumar, Mr. Jain Bharat, Dr. Vadnere G.P.

ABSTRACT

The purpose of the present study was to prolong the gastric residence time of Famotidine by developing gastric floating drug delivery system (GFDDS). And to study influence of different polymers on its release rate. using gas-forming agents, like sodium bicarbonate, citric acid. Floating tablets were prepared by wet granulation method using PVP K-30 as a binder and the other polymers include Xanthan gum, HPMC K100M, six different formulations with the varying concentrations of polymers were prepared and the tablets were evaluated in terms of their pre compression parameters like bulk density, tapped density, Haunsner ratio,angle of repose, compressibility index, post compression physical characteristics, in vitro release, buoyancy, floating lag time (FLT), total floating time (TFT) and swelling index. All the formulations showed good floating lag time i.e. less than 3 mins. The batch containing combination of Xanthan gum and HPMC 100M (i.e. F-VI) showed total floating lag time more than 12 h., the highest swelling index among all the prepared batches (i.e. 230 %).The drug release was found to follow zero order kinetics.

Keywords: Famotidine, floating, floating lag time, floating time.