Abstract

EFFECT OF POLYMERS ON DRUG RELEASE IN THE FORMULATION OF SUSTAINED RELEASE MICROSPHERES OF FLUVASTATIN

Raheela Sabeen* and M. Mahesh

ABSTRACT

In the present work, bioadhesive microspheres of Fluvastatin using HPMC, Carbopol, Eudragit EPO as polymers were formulated to deliver Fluvastatin via oral route. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 66.45±0.04 μm to 93.45±0.09 μm and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in vitro mucoadhesive study demonstrated that microspheres of Fluvastatin using HPMC as polymer adhered to the mucus to a greater extent than the microspheres of Fluvastatin using Carbopol as polymers. The in vitro drug release increase with increase in the polymer concentration. Based on the results of evaluation tests formulation coded T3 was concluded as best formulation. The best fit model was found to be zero order release kinetics .

Keywords: Fluvastatin, HPMC, Carbopol, Eudragit EPO, Microspheres.