Abstract

DRUG UTILIZATION EVALUATION OF ANTIBIOTICS IN VENTILATED CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

Thomas Saju*, Jerin Mathew, Irin Anna Martin, Sujith K., Mathew Ninan and Dr. Santhosh M. Mathews

ABSTRACT

Chronic Obstructive Pulmonary Disease is the most common preventable and treatable disease. An exacerbation is defined as a change in the patient’s baseline symptoms. A prospective observational study was done to evaluate the use of antibiotics, to check potential drug-drug interaction, to determine WHO prescribing indicators, to perform cost analysis and evaluate Hospital Anxiety and Depression Scale. Out of 80 patients 54 were male and 26 were female. Majority of patients in the study belong to the age group 66-75. The most used antibiotic was ceftriaxone. Antimicrobial sensitivity test was done for only 18 (62%) patients. From the study of drug interaction severity total and antibiotic drug interaction, moderate severity has highest incidence. Azithromycin was found to be the most interacting antibiotic. Average number of drug per patient was 15.65. Average drug cost per patient is Rs.8125.03. Out of 80 patients only 61 (43 male and 18 female) patients were able complete HADS questionnaire. There is a significant correlation between anxiety and depression. The most prescribed route of administration was intravenous (72.88%) followed by oral (26.27%) and others (1%). The most sensitive antibiotics were Meropenem, Vancomycin, Sulbactam, and Azithromycin. Klebsiella pneumoniae was the most occurred microorganism. The need for clinical pharmacist and computerized prescription checker is essential to minimize drug interaction and to provide cost effective drug therapy. Restricted antibiotics should be used only after performing antimicrobial sensitivity tests. Psychological assessment is essential for ventilated Intensive Care Unit patients.

Keywords: Drug utilization evaluation, antibiotics, COPD, cost analysis, drug interaction, HADS.