Abstract

IS ARTIFICIAL SKIN IS ALTERNATIVE TO ANIMAL TESTING? A MINI REVIEW

Muhammed Anwar*, K. Rashid, Safdar, Shana Thasni, P. S. Shiji Kumar and A. Sherin

ABSTRACT

On the artificial skin models have drawn attention as an alternative to animal testing to access the safety and toxicity of products. Driven by regulations authorities and industry demands, various models of artificial skin have been developed by combining various biomaterials and human cells and the use of various techniques, Carefully designed artificial skin models that closely mimic human skin can be very valuable and effective tools to replace in-vivo animal testing for the evaluation of the safety and efficacy in the field of pharmaceutical industry as well as for basic studies on cell-cell interaction, cell-extra cellular matrix interaction, tissue formation and development. The significance of artificial skin in pharmacological evaluation is not completely understood. Here we trying to describe the wide opportunities of artificial skin in pharmacological and cosmetic domains as alternative to in-vivo testing.

Keywords: Artificial skin models, Animal alternatives, Safety evaluation, Toxicity, Animal-free testing.