Abstract

PROSPECTIVE EFFECT OF ANTI-TUBERCULOSIS DRUGS ON LIVER OF ADULT MALE ALBINO RATS

Hader Fawzy Darwish*, Bosy Azmy Abd El-Motelp, Samiha Mohamed Abd El Dayem, Fatma Mokhtar Fouda

ABSTRACT

Tuberculosis, is a chronic transferrable disease caused by Mycobacterium tuberculosis, could invade all organs but chiefly affect the lungs. The aim of this study was to evaluate the effect of anti-tuberculosis drugs namely rifampicin and pyrazinamide on the liver of albino rats. The effect of both drugs was determined by measuring the marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the liver. Liver toxicity was induced by oral administration of rifampicin at a dose of 300 mg/kg of body weight (21 consecutive days) the rifampicin treated rats showed a significant increase in the marker enzymes such as AST and ALT, but the oral administration of different doses of pyrazinamide 250, 500 and 1000 mg/kg body weight (45 consecutive days) showed non-toxic effect. The results of the present study suggest that rifampicin showed hepatotoxic effects.

Keywords: Tuberculosis, Rifampicin, Pyrazinamide, Hepatotoxicity.