DESIGN AND EVALUATION OF IMIDAPRIL TRANSDERMAL PATCH CONTAINING SOLID -LIPID NANO PARTICLES FOR TOPICAL DELIVERY
B.V.Ramana*, C.S.Parameswari , M.Kishore Babu, M.Vasavi Chandrika*,P.V.Nagarani
ABSTRACT
The objective of the study was to design and evaluate the transdermal
patches containing imidipril loaded solid lipid nanoparticles with an
aim to improve the therapeutic efficacy pertaining to hyper-tension.
The imidipril loaded nanoparticles were prepared by homogenization
followed by ultra sonication technique using the excipients such as
lipid (dynasan 118),surfactant (polysorbate80) and emulsifier (soya
lecithin).The patches were prepared by solvent casting technique using
the polymers such as Hpmc,EudragitRS100.For optimization of solid
lipid nanoparticles the experiment was carried out by varying the ratios
of drug. The influence of parameters such as pH, sonic content, effect of dispersion media,
ionic etc was investigated. Solid Lipid Nanoparticles were characterized by subjecting them
to particle size analysis and zeta potential measurement using photon correlation
spectroscopy, malvernzetasizer, DSC, IR & XR&D analysis. The results of the invitro drug
release profile from nanoparticles were found to be sustained with a release of at the end of
24hrs. Surfactants at 3% and emulsifier at 1.5% were observed to be vital in entrapment
efficiency in sln’s for the effective usage of imidipril in the treatment of hypertension
,Further better drug permeability was ensured from the formulation ‘F3’ when incorporated
in a transdermal films when compared to the others at the end of 24hrs.
Keywords: Nanoparticles, Imidapril, Dynasan, Polysorbate 80, Transdermal, Topical.
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