Abstract

MICROWAVE ASSISTED SYNTHESIS OF SOME PYRIMIDINE LINKED THIADIAZOLIDINES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES

Kalpana A. Palaspagar and Pradip P. Deohate 

ABSTRACT

In the present work efforts are made for microwave assisted synthesis and characterization of series of 1-(5-aryl/alkylimino-2-phenylimino-[1,3,4]-thiadiazolidin-3-yl)-2-(4,6-dimethyl-pyrimidin-2-yl-amino)-ethanones. The reaction initiated by reacting 2-amino-4,6-dimethyl-pyrimidine with ethyl chloroacetate to give ethyl (4,6-dimethyl-pyrimidin-2-yl-amino)-acetate which on further reaction with hydrazine hydrate afforded (4,6-dimethyl-pyrimidin-2-yl-amino)-acetic acid hydrazide. The hydrazide was reacted with N-aryl/alkyl isothiocyanates and further with N-phenyl isocyanodichloride and basified to afford the title compounds exhibiting differently substituted constrained pharmacophores. The purity of compounds was checked by TLC and constituents of compounds delineated by chemical transformations, IR, 1H-NMR and mass spectral studies. The title compounds were assayed for their biological activities.

Keywords: Microwave, pyrimidine linked thiadiazolidines, biological activities.