Abstract

TO EVALUATE TRACE ELEMENTS, ANTIOXIDANT AND OXIDATIVE STRESS DURING PREECLAMPSIA AND ECLAMPSIA

Sonali Rajdev* and Dr. B. K. Agarwal

ABSTRACT

Background: Our aim of the study is to investigate trace elements, antioxidant and oxidative stress during pregnancy in preeclampsia and eclampsia. Thus, we sought to determine concentrations of plasma copper, iron and zinc at PE and eclampsia stage, and related it to the subsequent development of PE and eclampsia. We also examined the ratios of copper, iron, and zinc, based on their inter-relationships in regulating the antioxidant defense system. Material and Methods: The present study was carried out in the Department of Biochemistry in association of Department of General Medicine. Biochemical parameters included: Iron, Zinc, Copper, Malondialdehyde (MDA), Glutathione. The study was carried out on Case group - 50 pre-eclampsia and eclampsia patients compare to Control group – 50 normal pregnant females. Selection criteria; Control: Normal pregnant females randomly selected from the hospital who is not suffering from any other medical disorder. Cases: All the patients of preeclampsia and Eclampsia will be admitted in the hospital. Inclusion criteria: Pregnant female suffering from preeclampsia and eclampsia. Exclusion criteria: Pregnant females suffering from any other medical disorder. Results: The mean serum concentrations of zinc, copper, and iron statistically significantly difference (P < 0.05) in pre-eclampsia and eclampsia patients in comparison to the control group. Oxidative marker between Case and control group was statistically significantly difference. MDA in case group was 2.56.0.27 nM/mL and Control 1.46 0.19 nM/mL. Antioxidant marker between Case and control group was statistically significantly difference. Conclusion: We found lower maternal plasma iron, zinc and copper were significantly decreased throughout pregnancy in who subsequently developed PE and eclampsia. We also found increase MDA in PE and eclampsia, when compared to pregnant women. In addition, we also found decrease of antioxidant such as Glutathione in PE and eclampsia, when compared to pregnant women.

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