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Kumari Aarti and Balwan Singh*



Nowadays the demand of oral dispersible tablets are very much accepted by old, youngsters and the patients who experiencing difficulty in swallowing. Labetalol is a medication of decision which is utilized in treatment of Hypertension & Angina. To improve the antihypertensive properties of active pharmaceutical drug it is desirable to develop its rapid acting dosage form hence a fast MDT (mouth dissolving tablets) of Labetalol is always superior decision. The most popular common polysaccharide Chitosan has been used for its best property of versatile applications in pharmaceutical industry. Superdisintegrants property of chitosan has been used to build up a quick mouth dissolving tablet by using a novel technique for treatment which can replace any other superdisintegrating. In this study oro-dispersible tablets of Labetalol has been prepared by using natural polymer Chitosan as superdisintegrant by direct compression method, in which design and characterization has been performed by using different concentration of Chitosan to prepare the dosage form with fast disintegration and improved dissolution to increase bioavailability. In this study ten formulations have been prepared and evaluated by pre-compression studies such as Angle of repose, Bulk density, Tapped density and Carr’s index were carried out to determine the flow property of powder. After compression of tablets post-compression studies were performed by evaluation parameter like thickness, hardness, friability, wetting time, weight variation, drug content, in-vitro disintegration time, water absorption ratio, in-vitro drug release and stability studies. It is concluded that all formulation disintegrated within time period of 65 seconds. The LA8 formulation was having higher percentage of drug release compared to others.

Keywords: Labetalol, Oro-dispersible tablets, Natural polymer, Chitosan superdisintegrants and direct compression.

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