Abstract

LIQUISOLID COMPACT TECHNOLOGY: A REVIEW

Sanjit N. Darwai*, Swapnil R. Patil, S. C. Atram

ABSTRACT

Liquisolid compacts were used to formulate water insoluble drugs in nonvolatile solvents and convert into acceptable flowing compressible powders by blending with selected powder excipients. By using this method dissolution rate and bioavailability of BCS class-II drugs can be increased. About 40-50%drugs available marketed water insoluble drugs. It is challenge to industry to increase solubility of unit dosage forms to overcome this liquid solid compact technology is best suitable one. On this study the pre-comprisable parameters like porosity, corsaldity index, flow behavior, power bed hydrophilicity, saturate solubility. Post compressibility parameters like uniformity, weight variation, hardness, friability, wet ability, time. In this we can use carrier (microcrystalline cellulose, starch, and lactose), coating materials (silica gel), and disintegrating agents. In this we can do flourier transform infra-red spectroscopy, differential scanning calorimeters (DSC), and differential scanning thermometer, x-ray diffraction. It could promise strategy in improvising dissolution of poor water-soluble drugs and formulating immediate release solid dosage forms.

Keywords: Liquisolid compacts, Bioavailability, Poorly soluble drugs, Dissolution rate.