Abstract

TO INVESTIGATE THE HOLD TIME STUDY OF ABACAVIR SULFATE TABLETS 300MG PREPACKAGED IN QUARANTINE AREA

Deepak P Pawar*, Dr. Prashant B Shamkuwar, Sheetal S Chavan

ABSTRACT

To validate the holding time of Abacavir sulfate tablets 300 mg prepackaged in quarantine area under the prevailing conditions. Abacavir Sulfate tablets 300 mg were subjected to hold time study at Initial, 30th, 60th and 90th days. The stored coated tablets were evaluated for the intact drug in the formula, and compatibility of the drug with the formulated excipient analyzed to determine the content uniformity (%) and other parameters which were compared with the pharmacopoeia limits. After storage of those coated tablets at different time intervals i.e. at Initial, 30th, 60th and 90th days it was ensured that the holding time of Abacavir sulfate tablets 300 mg prepackaged in quarantine area is within the limits of acceptance criteria. From the data it is concluded that the coated tablets of Abacavir Sulfate tablets 300 mg should be stored upto 90th day. Therefore, extremely accurate hold-time data were obtained. In light of this data the correct trends in hold-time study as a function of storage period for Abacavir Sulfate tablets 300 mg coated tablets can be established.

Keywords: Abacavir Sulfate tablets 300 mg; Content Uniformity; Pharmacopoeia limits.