Abstract

IN-VITRO ANALYSIS OF GENISTEIN ISOLATED FROM LABLAB PURPUREUS LINN INHIBITED ON LPS INDUCED INFLAMMATION IN HPBMCS CELLS VIA A TLR MEDIATED NF-?B PATH WAY AND OXIDATIVE STRESS CONDITION

C. Pramod*, Prof. Dr. Sudhakaran Nair, Prof. Dr. Jyoti Harindran and Prof. Dr. Ratheesh

ABSTRACT

Medicinal plants are considered as a rich resource of ingredients which can be used in drug development. Lablab purpureus a slender twining shrub, belonging to Fabaceae family. Seed podes extract of related Lablab species reported to have anti inflammatory and analgesic activity Phyto-estrogenic substances can manipulate the inflammatory function in animals. The histological changes in the paw tissue synovial changes and radiological change in joints of the methanolic extract (MEL) was observed. In this study attempt was made to characterise antiinflammatory property in relation with histological and synovial changes in the paw tissue. Significant antiinflammatory and analgesic property of the plant extract was observed (p<0.05) when compared with control. Phytochemical screening showed presence of polyphenolic, alkaloids and flavonoids etc. Biological properties including antioxidant activities reported in some of these constituents.

Keywords: Lablab purpureus a slender twining shrub, belonging to Fabaceae family.