Abstract

CLINICAL RESEARCH AND ROLE OF DIETARY SUPPLEMENT IN THE TREATMENT OF MIDDLE EAST RESPIRATORY SYNDROME CURRENT STATUS

Virendra Kumar Bheliya* and Adarsh Kumar Pathak

ABSTRACT

In this review, we have noted currently ongoing developments for the treatment of infections and dietary supplements for symptomatic treatment to heal the patient's health, as well as the structure and spread of the virus which will help in early detection and treatment of the disease. We did a report search on Medline, Cochrane, Elsevier, Google Scholar and Research Gate database, where all the reports are taken in English language. Severe outbreaks of coronaviruses occur on the health of humans and other animals. Early symptoms include fever, cough, and labored breathing, pneumonia and diarrhea. There is currently no vaccine or specific treatment available for a viral infection, although several specific vaccines and treatments are in development. Middle East Respiratory Syndrome (MERS) virus does not spread easily from one to another unless close contact occurs. In particular, the infection spreads only when there are problems such as insufficient or inappropriate in the prevention and control of infection. Molecular malformation is the same single standard RNA in the genome of both MERS-Coronavirus and severe acute respiratory syndrome (SARS) coronaviruses. Similar to SARS-Coronaviruses, MERS-Coronaviruses S2 protein subunit (it dissociates from S1, at the time of membrane fusion) is responsible for membrane fusion at regions included heptad repeat 1 (HR1) and 2 (HR2). It form a 6-helix bundle (6-HB) fusion core, exposing a hydrophobic fusion peptide inserted into the host membrane and bringing the viral and host membranes into proximity for fusion. This stage will guide rational design to anti-MERS-Coronaviruses therapeutics specifically targeting through fusion of core structure of MERS- Coronaviruses as fusion inhibitors. Dietary supplements will be very good for symptomatic treatment which will help in improving the health of the patient. In conclusion, the MERS virus is proving to be very dangerous for the organisms, which is challenging the health and economic.

Keywords: Viral Infection, Middle East Respiratory Syndrome Coronavirus, Severe Acute Respiratory Syndrome Coronavirus, Potential Therapy, Dietary Supplement.