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  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

A REVIEW ON FAST DISSOLVING BUCCAL FILMS

Harsha B. Sakharkar*, Swapnil R. Patil and Monika Jadhav

ABSTRACT

Fast dissolving buccal films is a novel oral drug delivery system offers new possibilities for drug delivery by providing the advantages of oral delivery coupled with the enhanced safety and efficacy of a drug molecule, enhanced onset of action, improved bioavailability by avoiding first pass metabolism and enzymatic degradation in the GI tract and convenience to special patient categories such as pediatrics, geriatrics and bedridden patients who experience difficulties in swallowing the conventional oral dosage form. This delivery system consists of a thin oral film, which is simply placed on the patient‟s tongue or any oral mucosal tissue (buccal/sublingual), instantly wet by saliva, rapidly hydrates and adhere onto site of application, where it disintegrates and dissolves to release the medication for oral mucosal absorption. More recently, fast dissolving films are gaining interest as an alternative to fast dissolving tablets to definitely eliminate patient‟s fear of chocking and overcome patient impediments. Fast dissolving films are formulated using polymers, plasticizers, sweeteners, flavor‟s and colors. Fast dissolving films were prepared by solvent casting, rolling, extrusion and solid dispersion method. The films evaluated for disintegration, dissolution, tensile strength, thickness, folding endurance and elastic modulus. This article overviews the advancements in oral dosage forms, formulation considerations, method of preparation, evaluation, marketed products and it also suggests that this delivery system can be adopted by various pharmaceutical companies in future at large scale.

Keywords: Fast dissolving buccal film, polymer, plasticizer, solvent casting, bioavailability enhancement.


[Full Text Article]

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