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Nikhil Arun Shete*, Wani V. B., Pawar V. V., Waghmare S. U., Mohan R. S. and Pawar M. S.


An oral push-pull system that can deliver drug for extended period of time has been developed and characterized. A bilayer osmotic drug delivery system was developed using a basic design consisting of an oral osmotic controlled push-pull pump system. This system require a preformed orifice for drug release, It contain semi-permeable membrane and water-soluble pore-formers in the coating membrane. When this system comes in contact with water, the flux forming agent get dissolve resulting in an in-situ formation of a microporous membrane. The push layer get contact with water and get swells and releasing the drug at a controlled rate. In case of drug which having short half life the frequency of dose administration is more like three to four times a day. Hence, an attempt was made to develop a 24 hours extends the release of the drug at predetermined rate. This offer significant patient benefits by reducing the side effects, enhanced efficacy and also reduce the frequency or number of daily doses compared to conventional therapies.

Keywords: Osmotic pump, Orifice, Push-pull system, osmotic agents, etc.

[Full Text Article]

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