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Abstract

BIOEQUIVALENCE STUDY OF TWO ORAL CHLORTETRACYCLINE HYDROCHLORIDE (CHLOORTETRA 20%® AND HYPERCHLOROACT®) IN BROILER CHICKENS

Ashraf Elkomy* and Mohamed Aboubakr

 

ABSTRACT

The present study was designed to assess the comparative bio-equivalence of Chloortetra 20%® and Hyperchloroact® in healthy broiler chickens after oral administration of both products in a dose of 20 mg chlortetracycline/Kg b.wt. Twenty four broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Chloortetra 20%®, while the 2nd group was designed to study the pharmacokinetics of Hyperchloroact®. Each broiler chicken in both groups was orally administered with 20 mg chlortetracycline/Kg b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 8, 12 and 24 hours after a single oral administration. The disposition kinetics of Chloortetra 20%® and Hyperchloroact® following oral administration of 20 mg chlortetracycline/Kg b.wt, revealed that the maximum blood concentration of chlortetracycline [Cmax] were 3.44 and 3.30 μg/ml and attained at [tmax] of 0.99 and 0.97 hours, respectively. In conclusion: Hyperchloroact® is bioequivalent to Chloortetra 20%® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) was 0.95, 0.94 and 0.93 respectively. These are within the bioequivalence acceptance range. Hyperchloroact® and Chloortetra 20%® are therefore bioequivalent and interchangeable.

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