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Abstract

IN VITRO EVALUATION OF ANTIOXIDANT, CYTOTOXIC AND HEMOLYTIC ACTIVITIES OF 3-HYDROXYCOUMARIN

Erwelly B. Oliveira∗, João S. B. Luz, Gleyka D. M. Santos, José Maria Barbosa-Filho, Rodrigo S. A. Araújo, Tiago F. Silva, Cláudio G. Rodrigues, Dijanah C. Machado, Eliete C. Silva and Paloma L. Medeiros

 

ABSTRACT

Coumarins are a group of natural phenolic compounds that shows several pharmacological activities and the 3-hydroxycoumarin represents as target valuable molecules against several diseases. This study aimed to investigate the antioxidant, cytotoxic and hemolytic activities of 3-hydroxycoumarin. Antioxidant activity was performed using 2,2′-diphenyl-1-picrylhydrazyl (DPPH). Cytotoxicity was estimated using MTT assay on J774 macrophages and their morphology analyzed by phase- contrast microscopy. Hemolytic activity was assessed lysis of the red blood cells under in vitro conditions. Our results indicate that 3-hydroxycoumarin behaved as an in vitro antioxidant (IC50: 67.69 ± 6.89 μg/mL), revealed cytotoxicity (CC50: 97.69 ± 9.41μg/mL) and morphological changes from 100 μg/mL and did not induce hemolysis. Further studies will be required to understand the probable mechanisms of action of this potential derivate.

Keywords: 3-hydroxycoumarin, antioxidant activity, cytotoxicity, hemolytic activity, morphological analysis.


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