EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF CAREYA ARBOREA AND ITS ROLE IN THE PANCREATITIS IN EXPERIMENTAL RATS
Sumia Fatima and Syeda Adeeba Insha*
ABSTRACT
The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Careya arborea and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The activity was evaluated for methanolic extract of Careya arborea both in in-vitro i.e., α-amylase inhibitory and in-vivo model i.e., high fat diet [(vanaspati ghee and coconut oil) 3:1ratio, orally] body weight, p. o. and Triton-X 100 (100 mg/kg, b.w; i.p.) induced hyperlipidemia at the dose of 100,150 and 200 mg/kg respectively. The biochemical parameters such as Total Cholesterol, Triglycerides, LDL-C, HDL-C, VLDL-C in high fat diet and also in Triton- X -100 along with Serum Amylase, Serum Lipase and Blood glucose levels were estimated to appraise its activity. A significant increase in the levels of biochemical Parameters was discerned in negative control and a reversal in the extent was seen in the treated group of animals engaged in the study. The histopathological evaluations of heart and pancreas samples were in support of the obtained results. Based on the results it can be suggested that Careya arborea leaves possess anti hyperlipidemic activity and has the potential in prevention of hyperlipidemia induced pancreatitis.
Keywords: Anti hyperlipidemic, Careyaarborea, Triton-X -100, High fat diet, ?-amylase, pancreatitis.
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