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Abstract

DESIGN AND DEVELOPMENT OF CO-CRYSTALS OF ACECLOFENAC AND PARACETAMOL AND ITS CHARACTERIZATION

Tejaswini Kande*, Pallavi Dhekale and Supriya Khatal

 

ABSTRACT

Paracetamol is a class III drug which has limited permeability and High solubility, aceclofenac is a class II drug which has High permeability and Low solubility, for overcome this problems co-crystallization method is used. Co-crystallization is the process to enhance the physical properties of drug molecule especially the solubility. Paracetamol is analgesic and aceclofenac belongs to anti-inflammatory drug (NSAID). category they are combined for use in tablet formulation’s-crystallization was used to combine two drugs in single solid phase and thus to achieve new approach for combination therapy. Using the new approach co-crystals of aceclofenac with Paracetamol were prepared. Co-crystallization of two drugs were carried out by using solvent evaporation and solution co-crystallization method. The saturation solubility was done to evaluate the solubility of co-crystals. Dissolution properties were determined and compared with the marketed tablet formulation. The prepared co-crystals have shown several times faster release than marketed tablet and optimized co-crystals were characterized by using FTIR, Dissolution study.

Keywords: Paracetamol, Aceclofenac, Solvent evaporation, Solution co-crystallization, Characterization.


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