Abstract

BIOCHEMICAL PROFILE ALTERATIONS OF LIPIDS IN ORAL SUBMUCOUS FIBROSIS

Ankita Raj*, Nitin Tyagi and Vivek Kumar Katiyar

ABSTRACT

Introduction: Oral Submucous Fibrosis (OSMF) in India has been attributed to the increased consumption of areca nut. Oral Submucous Fibrosis (OSMF) is a chronic disease of the oral cavity which is characterized by an epithelial and sub-epithelial inflammatory reaction followed by fibro elastic changes in the mucosa. Materials & Methods: The present study was aimed to estimate serum lipid profile i.e. Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL-C), Low Density Lipoprotein (LDL-C), Very Low Density Lipoprotein (VLDL-C) in Moderate Oral Submucous Fibrosis and compared with controls. The study subjects were divided into 2 groups i.e. Group-I (Moderate Oral Submucous Fibrosis), Group-II (controls). Group-I includes n=50 patients of clinically diagnosed and histopathologically proven of Moderate Oral Submucous Fibrosis. They were in the age group of 20-45 years. Group-II (controls) were age and sex-matched, apparently healthy volunteers (n=50) were included in this study. Serum lipid profile was analyzed in all study subjects using fully automated Clinical Chemistry analyser Siemens ADVIA 2400. Results: The present study shown statistically significant decreased serum levels of Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C) and Very Low Density Lipoprotein Cholesterol (VLDL-C) levels in group-I when compared with group-II. Conclusion: The results of the present study showed that there is an inverse relationship between lipid profile and the presence of OSMF. The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity.

Keywords: Areca nut chewing, Oral Submucous fibrosis, Lipid profile, Oral Cancer.