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*Shafura S., Babitha V., Harish K. H., Jayanthi C. and Hanumanthachar K. Joshi



Background: Curcumin contains 80% of the curcuminiods (4-5%) of the rhizomes of Curcumin longa L and saffron. This poly phenol regulates various targets through direct interaction or modulation of gene expression. Despite well documented clinical benefits in colon disorders and safety profile, curcumin has limited pharmaceutical role owing to reduced water solubility, instability in alkaline (<1%). This demands administration of multiple and large doses(0.4-8gm) of curcumin to achieve intended therapeutic benefits. Several strategies have been explored to enhance curcumin delivery to the colonic tissues including micro encapsulation using non digestible polysaccharide developed as bio responsive drug delivery systems. The aim of the study was to formulate curcumin alginate micro beads of curumin. Method: Micro beads collected from the slurry were dried at 30°C for 6hr and stored in an air tight container. % drug loading of the formulation was assessed by UV spectroscopy at 425nm. Average particle size and yield were determined by optical microscopy and gravimetry respectively. % swelling and release profiles in SGF and SIF containing 02% tween 80 were plotted. Drug polymer interaction were assessed by FTIR spectroscopy. Also to assess pharmacokinetics study in rats and the mucoadhesion properties of beads. Result and conclusion: Formulation 4 found to be most optimum with reference to all the parameters tested – yield, particle size, encapsulation efficiency, swelling behavior, sustenance of release, mucoadhesion, curumin – polymer compactability by FTIR. The optimized formulation F4 also possess good color, appearance, and texture with good flow properties. This formulation has released nearly 0.25% of it’s pay load in the first 2hr at SGF and 0.24% in SIF at the end of 1.68%, 0.24% at 24hr, and at the end 1.68% at 96hr at SCF. Curcumin cargo is available for delivery in the colonic region after transit through stomach and small intestine.

Keywords: Curumin, microbeads, alginate, tween80, span80, pharmacokinetics, mucoadhesiveness.

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