Abstract

ANTI-INFLAMMATORY ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE LEAVES OF LUFFA ACINATA BY CARRAGEENAN-INDUCED PAW EDEMA MODEL

Pankaj Kumar Bhaskar*, Dr. Sailesh Narayan, Dr. Shailendra Bindaiya,
Dr. Shailendra Lariya, Ajay Rathore and Vinod Kumar Chandel

ABSTRACT

The objective of the present study was to evaluate the anti-inflammatory activity of hydroalcoholic extract of the leaves of luffa acinata for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine to treat inflammatory and painful diseases. Methods: Hydroalcoholic extract of the leaves of luffa acinata was prepared by cold maceration. Results: The anti-inflammatory activity was evaluated using carrageenan -induced paw edema models in wistar albino rats. the anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. the hydroalcoholic extract of the leaves of luffa acinata has shown significant (p < 0.05) inhibition of paw oedema, 40% and 55% on 4th hour at the doses of 100 and 200 mg/kg, respectively. Conclusion: The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.

Keywords: Anti-inflammatory activity, Hydroalcoholic extract of the leaves of luffa acinata, paw edema model, dilcofenac as standard.