Abstract

ANTIULCEROGENIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF RHIZOMES OF CURCUMA AMADA BY INDOMETHACIN INDUCED GASTRIC ULCER IN ALBINO RATS

Ajay Kumar Sahu*, Dr. Sailesh Narayan, Dr. Shailendra Bindaiya, Dr. Shailendra Lariya and Ajay Rathore

ABSTRACT

The present study was performed to evaluate the antiulcerogenic activity of hydroalcoholic extract of rhizomes of Curcuma amada by indomethacin induced gastric ulcer in Albino rats. Effect of different doses of hydroalcoholic extract of rhizomes of Curcuma amada, indomethacin on volume of gastric secretion, pH, free acid, total acid and ulcer index were observed. In addition, the effect of low dose of hydroalcoholic extract of rhizomes of Curcuma amada in combination with low dose of ranitidine on the above parameters were studied. Hydroalcoholic extract of rhizomes of Curcuma amada (100 and 200mg/kg), Ranitidine (100 mg/kg) produced significant antiulcer effect. Low doses of, ranitidine and hydroalcoholic extract of rhizomes of Curcuma amada did not alter above parameter significantly. Combined administration of low dose of ranitidine with hydroalcoholic extract of rhizomes of Curcuma amada shows significant antiulcer effect where the reduction of gastric secreation, acidity and ulcer index with simultaneous increase in gastric pH.

Keywords: Hydroalcoholic extract of rhizomes of Curcuma amada, ranitidine, indomethacin induced ulcer, gastric secretion, pH, free acid, total acid and ulcer index.