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Abstract

SPECTROSCOPIC STUDIES THE INTERACTION OF BIO-MOLECULES WITH IONIC LIQUIDS: A COMPARATIVE STUDY

Manoj Kumar Banjare* and Ramesh Kumar Banjare

 

ABSTRACT

The interaction between imidazolium based ionic liquids (ILs) with two globular protein is study to very important since of the extensive use of ILs as protein stabilizer in the recent years. In this work, the Interaction of serum albumin i.e., human serum albumin (HSA) and bovine serum albumin (BSA) with two ILs i.e., 1‐butyl‐3‐methyl‐imidazolium octylsulphate (BmimOS) and 1‐decyl‐3‐methylimidazolium tetrafluoroborate (DmimBF4) have been investigated using Uv-visible spectroscopy and DLS techniques. The thermodynamic properties demonstrate that very weak interactions exist between HSA/BSA and BmimOS/DmimBF4. The conformational changes of HSA/BSA were monitored by DLS analysis. Temperature‐dependent ultraviolet (UV) measurements were done to study the thermal stability of HSA/BSA. The thermal stability of BSA in the presence of ILs follows the trend BmimOS > DmimBF4 and in the presence of more hydrophobic IL, destabilization increases rapidly as a function of concentration.

Keywords: Albumin, Ionic liquids, UV-vis spectroscopy and dynamic light scattering.


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