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Abstract

PREPARATION AND CHARACTERIZATION OF ACECLOFENAC TOPICAL GEL

Bhandari Neeraj* and Dr. Gupta Rajesh

 

ABSTRACT

The present investigation involves formulation of Acelofenac topical gel having by modification of the “cold dispersion” method described by Schmolka. Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities, similar to indomethacin and diclofenac and due to its preferential cox-2 blockade, it has better safety than conventional NSAIDs with respect to adverse effects on gastrointestinal and cardiovascular system. Aceclofenac is used in treatment of osteoarthritis, rheumatoid arthritis, acute lumbago, and dental pain condition. The formulation of Acelofenac topical gel was prepared using HPMC, Carbopol 974 P and Sodium CMC in three different batches. Aceclofenac topical gels are prepared in this study. Studies showed that drug release was decrease with increase in gelling agent concentration because polymer concentration increases, viscosity increases. The best release pattern of drug was observed F15- Poloxamer-407. So, then release pattern order Poloxamer-407> HPMC>Carbopol-940> Carbopol-934. On the basis of physical parameters and release pattern F2, F6, F11, F15 selected as best formulations. Further stability of selected formulation had been done on different temperature such as on 4°c, 25°c and 37°c for 3 months. There were no significant changes in the viscosity, and physical appearance of the gel. After storing at different temperature conditions for three months.

Keywords: COX- 2, Lumbago. Rheumatoid Arthritis.


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