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Ausaf Butool*, Hafsa Hussaini, Juveria Nausheen, Mohd Mudabbir, Dr. Y. Rajesh, Dr. Anupama Koneru



This article has been written to briefly review the process of lead optimization and the role played by focused libraries through the data that is currently available. The article contains an in-depth description of the process of lead optimization or lead identification which includes the process that a chemical compound has to undergo in order to become a potential drug to show its therapeutic effects when incorporated into medicines. The various methods used in this process have also been clearly stated such as high-throughput screening. The article aims at giving a thorough yet concise description to the method of lead Optimization. High-throughput screening is one of the methods used for scientific and analytical experiments which are most prominently used in the process of drug discovery. It is also significant to the fields of biology and chemistry. Chemical screening libraries are mostly used in high-throughput screening which particularly focuses on the analysis of small molecules. This process is efficiently used in drug and lead compound discovery and also the evaluation of effectors molecules and receptors. Screening libraries also allow the fastest and most cost efficient analysis of the effects of a variety and wider range small molecules on a certain or given target or biological system.

Keywords: Target, Drug, Design, Modelling, Lead Molecules, Docking, Lead Compounds, High Throughput Screening.

[Full Text Article]

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