Abstract

DIABETES MELLITUS ON CHRONIC RHINOSINUSITIS AND SINUS SURGERY OUTCOME IRAQ

Dr. Nathem Hurrein Kashish*, Dr. Emad Malik Abdalrida and Dr. Saad Mohammed Fenjan

ABSTRACT

Objective: Patients with diabetes mellitus (DM) are known to be liable to infection. However, the association between diabetes and chronic rhinosinusitis (CRS) has not been well studied. We sought to determine the effects of DM on CRS culture results and quality of life (QOL) after functional endoscopic sinus surgery (FESS). Methods: We conducted a retrospective cohort study. Adult CRS patients undergoing FESS were recruited from 10/1/20016 to 12/111/2019. Patient demographics, comorbidities, medication use, Lund-Mackay CT scores were collected prior to FESS. Intraoperative culture was obtained. Preoperative and 1-, 3- and 6-month postoperative QOL was measured by the 22 item Sinonasal Outcome Test (SNOT-22) scores. A mixed effects model was performed for analysis. Results: Among the 476 CRS patients included, (5.05%) had DM. Compared to non-DM patients, DM patients were significantly more likely to have Pseudomonas aeruginosa (26.32% versus 7.56%, p=0.004) and gram negative rods (26.32% vs. 8.96%, p= 0.013), but there were no significant difference in the prevalence of Staphylococcus aureus; DM patients were also significantly more likely to have nasal polyps and gastroesophageal reflux disease. Additionally, DM patients had significantly less improvement of postoperative SNOT-22 scores from baseline to 6-month follow-up than non-DM patients (adjusted mean=11.14, 95% CI (0.14, 22.15), p=0.047) after adjusting for all the other risk factors for CRS. Conclusion: DM patients may be prone to gram negative bacterial sinus infections, and have significantly worse short-term postoperative QOL. Special postoperative care may need to be considered in CRS patients with DM.

Keywords: Chronic rhinosinsitis; diabetes mellitus; infection; quality of life; Pseudomonas aeruginos.