Abstract

EFFECT OF ANTITHYROID DRUG THERAPY IN ADULT HYPERTHYROIDISM-A PROSPECTIVE OBSERVATIONAL STUDY

G. Vanitha and M. Kulandaiammal*

ABSTRACT

Background: Hyperthyroidism is common worldwide. The Prevalence of hyperthyroidism in India is 3.9%. There are several causes of hyperthyroidisim and the most common cause in females is due to Graves disease (50%). It lead to complications like osteoporosis, cardiovascular collapse and life threatening events. Objectives: The Primary objective is to assess the effect of antithyroid drugs in adult hyperthyroidism and the Secondary objective is to evaluate the adverse effects of antithyroid drugs. Methodology: This was a 3 months (march - may 2019) study. 60 patients were enrolled from the department of internal medicine, Government Stanley medical college after fulfilling inclusion &exclusion criteria and followed at the end of each month interval. The parameters noted are age, sex, disease distribution, response to treatment by Free T4 level and adverse drug effects. Results: Among 60 patients enrolled 50 patients were grave„s disease and 10 patients multinodular goitre. They were treated orally with T.Carbimazole, T.Propranolol and followed up for 3months,from the results palpitation was reduced in 14 patients, no significant weight gain in 20 patients and Free T4 level reduced in 44. Adverse effects observed was abdominal discomfort in (13 in no), itching ( 7 ) and rashes ( 2) noted. Conclusion: In this study 60 patients diagnosed with hyperthyroidism in tertiary care hospital were analysed and their Free T4 level reduced in maximal number of patients in 3months and whereas palpitation symptoms improved only minimal number of patients. There was no significant change in weight gain.

Keywords: Hyperthyroidism, carbimazole, propranolol, adverse effects, palpitation.