Abstract

ANTIPYRETIC ACTIVITY OF ARGYREIA NERVOSA IN YEAST INDUCED PYREXIA

Md. Abul Hassan*, Nafisa Yesmin, Md. Amirul Islam and Md. Aminur Rahman

ABSTRACT

Background: Bangladesh is a Bay of Bengal which has large Medicinal plants from the ancient era of its natural source. By the consideration of its traditional value Argyreia nervosa is an important medicinal plant of family Convolvulaceae is tested for antipyretic activity. Methods: The effect of aqueous extracts of leaves was tested on yeast induced pyrexia in albino rats. The drug dosage of 300, 400 and 500 mg/Kg body weight was experienced on the fever induced rats. It was compared with the standard drug Paracetamol (150 mg/Kg body wt) fed rats. Results: The aqueous extract of leaves presented significant antipyretic activity after 2 hours in the dosage of 300, 400
and 500 mg/Kg body wt as that of compared standard drug paracetamol. The Study was carried out on healthy albino rats weighing about 150-200 g, using brewer’s yeast-induced pyrexia for antipyretic study. Conclusions: The Study concluded that the extracts of Argyreia nervosa leaves possessed pharmacologically active constituent(s) which interfered responsible for antipyretic Activity which were comparable with standard drugs.

Keywords: Antipyretic activity, albino rats, Argyreia nervosa, paracetamol, yeast induced pyrexia.