Abstract

COMPARATIVE ANTHELMINTIC ACTIVITY OF CARICA PAPAYA LINN LEAVES AND PIPER BETLE LINN LEAVES

Manali M. Bhide* and Dr. Sachin A. Nitave

ABSTRACT

In the present work, experiments were conducted to evaluate the possible anthelmintic effects of alcoholic & aqueous extracts of Carica papaya Linn leaves and alcoholic & aqueous extracts of Piper betle Linn leaves on Indian earthworm (Pheretima posthuma) at different concentrations i.e. 10, 20, 30, 40 & 50 mg/ml. The Albendazole 20mg/ml & Distilled Water were used as a standard & control respectively. Results were expressed in terms of time for paralysis and time for death of worms. The phytochemical testing of extracts of Carica papaya Linn leaves & Piper betle Linn leaves was done & it showed that Carica papaya Linn leaves contains Alkaloid, Glycosides Flavonoid, Saponin, Steroid and Anthraquinones & Piper betle Linn leaves contains Saponin, Glycoside, Alkaloid, Tannin. It was noticed in this investigation that the time of paralysis & death of worms was the dose dependent. The result revealed that leaves extracts of Piper betel Linn has better activity than Carica papaya Linn leaves extracts.

Keywords: Anthelmintic, Pheretima posthuma, Piper betle, Carica Papaya, alcoholic, Albendazole.