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  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2020 Issue has been successfully launched on 1 January 2020.

Abstract

CYCLOSPORIN INDUCED RENAL DAMAGE: A CASE REPORT

Dona Johnson*, Arshad K. T., Aneeta Jacob, Amala T. A., Sanjana Suresh

ABSTRACT

Cyclosporin is lipophilic polypeptide having 11 aminoacids. It have a unique immunosuppressive activity. It mainly acts on lymphocytes particularly helper T cells to produce suppression in cell mediated immunity. Their action is mainly by forming complex with cyclophilin in the cytoplasm. This complex then binds to calcineurin which is a calcium and calmodulin dependent phospholase. This leads to the activation or translocation of a nuclear factor, which binds and transcribe the interlukin 2 gene. Cyclosporins also inhibit other cytokines including interferones and interlukins.[1]

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