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Abstract

DEVELOPMENT AND EVALUATION OF FLOATING MICROENCAPSULES OF ILAPRAZOLE BY HOT MELT GRANULATION METHOD

*Dr. Archana D. Kajale, Dr. Shilpa R. Gawande, Dr. Bharati V. Bakde, Dr. Madhuri A. Channawar, Medhavi Kude and Priyanka Chirde

ABSTRACT

Hot melt granulation has been found to be the most efficient method for preparing numerous types of drug delivery system and their dosage. In the past, Film coating technology was used. Hot melt granulation technique was not widespread in the past. But due to its several advantages, hot melt granulation has now been accepted on large scale in the pharmaceutical industry. Hot-melt coating (hot melt granulation) as a solvent-free technology grants faster and more economic coating processes with reduced risk of dissolving the drug during the process. Moreover, traditional coating equipment can be modified to enable the hot melt granulation process. The current work elaborates the mechanism of hot melt granulation over traditional method for sustained release of drug and long lasting effect. Hot melt granulation has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). In the present study i;e formulation and evaluation of floating microencapsulation of Ilaprazole, stearic acid was used as base and various polymers like HPMC K100 M, Guargum, Carbapol 934, ethyl cellulose were used in various concentrations. From this formulations ethyl cellulose in the concentration of 1% (F8) gives sustain drug release as 99.45% for 12 hr and follows zero order kinetics. Where other polymers i;e HPMC K100 M, Guargum, Carbapol 940 was not able to retain the drug release for 12 hrs in various concentrations.

Keywords: Microencapsulation, Hot melt Granulation, Stearic acid, Ethyl cellulose, Ilaprazole.


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