Abstract

BIOCHEMICAL EFFECTS OF BASIL AND MARJORAM ON ULCERATIVE GASTRITIS INDUCED EXPERIMENTALLY IN RATS

Omnia M. Abdelhamid, Alshaimaa M. Said*, Ragaa S. Hussein

ABSTRACT

The present study was carried out to explore the effect of ethanolic extract of basil and marjoram on experimentally induced ulcerative gastritis. Forty adult male albino rats were divided into four groups; control group, ulcerative gastritis group rats received (1 mL/rat) ethanol once orally, basil treated group and marjoram treated group administered basil extract and marjoram extract at dose 200 mg/kg and 250 mg/kg daily for two weeks respectively after induction of gastritis. Ulcerative gastritis group revealed a significant increase in gastric malondialdehyde (MDA), myeloperoxidase (MPO) activity, proinflammatory cytokines (TNF-α and IL-1β). While the activity of gastric antioxidant enzymes and glutathione level showed significant decrease. Treatment with ethanolic extracts of basil and marjoram significantly decreased gastric (MDA), (MPO), proinflammatory cytokines (TNF-α and IL-1β). In addition, it significantly increased the activities of gastric catalase (CAT), superoxide dismutase (SOD) and (GSH) level when compared to ulcerative gastritis group. From these results we could conclude that, basil and marjoram had a significant ameliorating effects against ethanol induced ulcerative gastritis possibly attributed to their antioxidant and anti-inflammatory properties.

Keywords: Ethanol, Basil, Marjoram, MPO, Ulcerative gastritis.