Abstract

EFFECT OF AMLODIPINE AND LYCOPENE IN AMELIORATION OF RENAL TOXICITY INDUCED BY CISPLATIN IN ALBINO RATS

Hanan A. Rizk, Ashraf Elkomy, Samar S. Ibrahim and Mohamed M. Elmahalawy*

ABSTRACT

The present research investigated whether Amlodipine and Lycopene could ameliorate the Cisplatin induced renal toxicity in rats. 80 male albino rats were randomly assigned into 8 equal groups (10 rats each). Group 1: Rats which served as Control group were injected (IP) saline once daily for 20 days. Group 2: Rats in this group were served as Saline group and were administrated orally 1 mL saline once daily for 20 days. Group 3: Rats in this group were served as Corn Oil group and were administrated orally 1 mL Corn Oil once daily for 20 days. Group 4: Rats in this group were served as Amlodipine group and were administrated orally (5 mg/kg/day) Amlodipine once daily for 20 days. Group 5: Rats in this group were served as Lycopene group and were administrated orally (10 mg/kg/day) Lycopene once daily for 20
days. Group 6: Rats in this group were served as Cisplatin treated group and were injected (IP) (6 mg/kg/day.), once at day 10. Group 7: Rats in this group were served as Amlodipine + Cisplatin group and were administrated orally (5 mg/kg/day) Amlodipine once daily for 20 days and injected cisplatin (IP) (6 mg/kg/day) once at day 10. Group 8: Rats in this group were served as Lycopene + Cisplatin group and were administrated orally (10 mg/kg /day) Lycopene once daily for 20 days and injected cisplatin (IP) (6 mg/kg /day) once at day 10. Our results revealed that cisplatin increases urea, creatinine, MDA and potassium level and decreases TAC, GSH, and sodium level while in groups of amlodipine and lycopene showed significant protection to rats' kidney from structural and functional changes associated with cisplatin. It can be concluded that Amlodipine and Lycopene could ameliorate the Cisplatin induced renal toxicity.

Keywords: Cisplatin, Amlodipine, Lycopene, Renal toxicity.