Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2020 Issue has been successfully launched on 1 January 2020.

Abstract

EFFECT OF AMLODIPINE AND LYCOPENE IN AMELIORATION OF RENAL TOXICITY INDUCED BY CISPLATIN IN ALBINO RATS

Hanan A. Rizk3, Ashraf Elkomy, Samar S. Ibrahim and Mohamed M. Elmahalawy*

ABSTRACT

The present research investigated whether Amlodipine and Lycopene could ameliorate the Cisplatin induced renal toxicity in rats. 80 male albino rats were randomly assigned into 8 equal groups (10 rats each). Group 1: Rats which served as Control group were injected (IP) saline once daily for 20 days. Group 2: Rats in this group were served as Saline group and were administrated orally 1 mL saline once daily for 20 days. Group 3: Rats in this group were served as Corn Oil group and were administrated orally 1 mL Corn Oil once daily for 20 days. Group 4: Rats in this group were served as Amlodipine group and were administrated orally (5 mg/kg/day) Amlodipine once daily for 20 days. Group 5: Rats in this group were served as Lycopene group and were administrated orally (10 mg/kg/day) Lycopene once daily for 20 days. Group 6: Rats in this group were served as Cisplatin treated group and were injected (IP) (6 mg/kg/day.), once at day 10. Group 7: Rats in this group were served as Amlodipine + Cisplatin group and were administrated orally (5 mg/kg/day) Amlodipine once daily for 20 days and injected cisplatin (IP) (6 mg/kg/day) once at day 10. Group 8: Rats in this group were served as Lycopene + Cisplatin group and were administrated orally (10 mg/kg /day) Lycopene once daily for 20 days and injected cisplatin (IP) (6 mg/kg /day) once at day 10. Our results revealed that cisplatin increases urea, creatinine, MDA and potassium level and decreases TAC, GSH, and sodium level while in groups of amlodipine and lycopene showed significant protection to rats' kidney from structural and functional changes associated with cisplatin. It can be concluded that Amlodipine and Lycopene could ameliorate the Cisplatin induced renal toxicity.

Keywords: Cisplatin, Amlodipine, Lycopene, Renal toxicity.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More