Abstract

CORRELATION OF SERUM URIC ACID (SUA) WITH PAIN SEVERITY OF OSTEOARTHRITIS

Ayuba Affi*, Dr. Mancha David, Dr. Pam Stephen, Dr. Longwap S.A., Dr. Amusa Ganiyu

ABSTRACT

Background: The cause is not fully understood. Serum uric acid (SUA) was identified as one of the principal endogenous danger signal release from injured cells and mediating SUA is also implicated in the progress of the disease. Aim: To determine the correlation of pain severity of osteoarthritis and levels of SUA, to find out the greater difference of osteoarthritis and age distribution of osteoarthritis and identify which joint part that is most affected to intervene with drugs. Materials and methods: One hundred and thirty two Panyam farmers above 40years who met the inclusive criteria were included in the study. Both sexes were included that did not have debilitating disease such as CLD, CCF, CVA or pregnant. Anthropometric measurements of weight using the standard standing weighing scaled and height were measured by meter rule. Overnight fasting blood samples were assayed for uric acid using the enzymatic uricase method and the enzymatic glucose oxidase method for glucose concentration respectively. Results: Out of the 132 farmers with 81 interventions and 51 controls, the prevalence of osteoarthritis was found to be 61.4%. It was found to be more in females than males. The mean age of the participants is 62.7years and 63.6years for control. The SUA was generally very high with a mean of 679.2 for intervention group and 390 for control group. The mean BMI for both intervention (26.54) and control (27.08) were slightly above the normal (<25) tending towards overweight. Both the systolic and diastolic blood pressure were within normal limits. The severity of pain was found to be neck and knee joints. Conclusion: This study revealed a very high prevalence of osteoarthritis among these farmers probably due to their occupation, heavy consumption of locally brewed alcohol and age. As an intervention study comprehensive health education was given and drugs such as allupurinol and moduretics were provided to the PHC. The pain of osteoarthritis has drastically reduced their work output and this can hamper harvest. Though with uncertainty of etiology, there are many risk factors that contribute to the progression of osteoarthritis including obesity, trauma, age and female sex. It is recommended that this population should have a regular health talk on their social habits and regular exercise.

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