Abstract

ORALLY DISINTEGRATING TABLETS: FORMULATION, PREPARATION, EVALUATION AND RECENT ADVANCES: A REVIEW

Tadious Chimombe, Subhankar Mukhopadhyay, Hanitrarimalala Veeroniaina, LiDong Han, Xiang Xu, Tao Juan,* and Wu Zhenghong,*

ABSTRACT

Orally disintegrating tablets (ODTs) are tablets with medicinal substances, which can rapidly disintegrate or dissolve in the oral cavity without using water. Their salient immediate release property in many ways make the ODT a popular oral dosage form in special circumstances and situations such as institutionalized patients, travelling patients and patients with swallowing challenges. In this review we will discuss on the latest development in formulation, preparation techniques including their suitability and selection, as well as evaluation of parameters of orally disintegrating tablets. Recent advances in the orally disintegrating tablet dosage form will also be discussed.

Keywords: Orally disintegrating tablets, Disintegration, Formulation, Preparation, Excipients, Evaluation.