Abstract

DIFFERENT APPROACHES TOWARDS THE SOLUBILITY ENHANCEMENT OF DRUG:A REVIEW

*Pramod R. Shinde, Balasaheb S. Parve, Shilpi Rawat, Sarita S. Rathod,Amruta B. Varandal

ABSTRACT

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Among all newly discovered chemical entities about 40% drugs are lipophilic and fail to reach market due to their poor aqueous solubility. Whereas only 8% of new drug candidates have shown both high solubility and permeability. Dissolution rate, absorption, distribution and excretion of a moiety depend upon its solubility characteristics.For BCS class II drugs, enhancement of solubility is important parameter before formulation of dosage form. Solid dispersion, Solvent evaporation Complexation, are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs but each approach has some limitation and advantages. Novel techniques like Nano-suspension, Supercritical processing, Cryogenic technology may allow greater opportunities in the delivery of poorly soluble drugs. The present review is devoted to various traditional and novel techniques for enhancing drug solubility to reduce the percentage of poorly soluble drug candidates eliminated from the development.

Keywords: Solubility, BCS Class, Solid dispersion, cyclodextrin.