COLON TARGETED MULTIPARTICULATE SYSTEM: HYDROGEL BEADS
Arpita R. Jaiswal*, Maulesh R. Vyas, Dr. Atanu Kumar Behera, Dr. Dhananjay B.Mesharam
ABSTRACT
Oral administration of different dosage forms is the most commonly used method due to flexibility in design of dosage form and patient acceptance, but the gastrointestinal tract presents several barriers to drug delivery. The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted into the colon, thereby reducing the systemic side effects. Different approaches are designed based on prodrug formulation, pH-sensitivity, time-dependency, microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres for colon targeting.Report suggests that drug carrier systems larger than 200 mm possess low gastric transit time due to physiological condition of the bowel in colitis. Therefore, we are considering the selective uptake of micron or sub-micron particles by cancerous and inflamed cells/ tissues a multiparticulate approach based on pellets, granules, microsphere or nanoparticle type formulation is expected to have better pharmacological effect in the colon. The review is aimed at recent advancements made in multiparticulate formulation approach for colon specific drug delivery. Microbeads are small, solid and free flowing particulate carriers containing dispersed drug particles both in solution or crystalline form, formulated from synthetic and natural polymers and can be in the size range of millimeter, micrometer or nanometer. For target delivery of such multiparticulate system directly to the colon is done with the help of enteric coat of natural and synthetic polymers.
Keywords: Colon specific, Inflammatory bowel diseases, Microbeads, Multiparticulate system.
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