Abstract

FLOATING DRUG DELIVERY SYSTEM: A NOVEL APPROACH TO PROLONG GASTRIC RETENTION

Paresh D. Parmar*, Saikat Pande, Saumil H. Shah , Shailesh N. Sonara

ABSTRACT

Conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach, in case of drugs which are less soluble at alkaline pH of intestine. Further drugs which produce their local action in stomach, get rapidly emptied do not get enough residence time in stomach. Hence, the frequency of dose administration in such cases is increased. To avoid these problems, various efforts have been made to prolong the retention time of drug in stomach. Floating drug delivery system (FDDS) is one of the most important approaches in prolonging the retention time of drug in stomach. FDDS is low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at the desired rate which results in a better control of the fluctuations in plasma drug concentration. Based on the mechanism of buoyancy, two types of technique employed for development of floating dosages form: effervescent and non-effervescent. This review given the detailed outline of floating drug delivery system with their advantages over the conventional drug delivery system and also include limitation. The purpose of this review is to compose the recent work going on this delivery system and provide valuable information related to formulation aspect to achieve prolong gastric retention and discussed the various challenges in it and measure to overcome them.

Keywords: Floating drug delivery system, Gastric retention, Plasma drug concentration