Abstract

POLYMERS USED IN MUCOADHESIVE DRUG DELIVERY SYSTEM - LATEST UPDATES

Dheeraj D. Chechare* and Dr. M. Siddaiah

ABSTRACT

Bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces amongst the surfaces of the biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to the biological surface for an extended period of time. Bioadhesive polymeric systems have been used in the development of products for various biomedical applications and surgical glue.Various biopolymers show the bioadhesive properties and have been utilized for various therapeutic purposes in medicine. The bioadhesive polymers can be broadly classified into two groups, namely specific and nonspecific. The specific bioadhesive polymers (e.g. lectins, fibrin) have the ability to adhere to specific chemical structures within the biological molecules while the nonspecific bioadhesive polymers (e.g. polyacrylic acid, cyanoacrylates) have the ability to bind with both the cell surfaces and the mucosal layer. The use of Mucoadhesive polymers is for the development of pharmaceutical formulations. Various other polymers which have Mucoadhesive property are HPMC, PEG, tragacanth, sodium alginate, guargum, MC, CMC, sodium CMC etc. The ideal characteristics of a mucoadhesive polymer matrix include the rapid adherence to the mucosal layer without any change in the physical property of the delivery matrix, minimum interference to the release of the active agent, biodegradable without producing any toxic by products, inhibit the enzymes present at the delivery site and enhance the penetration of the active agent. Current use of mucoadhesive polymers to increase contact time for a wide variety of drugs and routes of administration has shown dramatic improvement in both specific therapies and more general patient compliance. Hence mucoadhesive polymers can be used as means of improving drug delivery through different routes like gastrointestinal, nasal, ocular, buccal, vaginal and rectal.

Keywords: Bioadhesion, Mucoadhesion, Mucoadhesive polymers, factors mucoadhesion theories.