Abstract

MAGNETIC AND HYPOXIC BIOSENSOR AS A VEHICLE FOR CHEMOTHERAPEUTICAL DRUGS

Mithaiwala Idris A.*, Suthar Hetal S., Ojha Sunil and Agrawal Amit

ABSTRACT

Cancer is deadly disease which is caused due to uncontrolled growth of the cells and forms an extra mass of tissue which is known as tumor. One of the biggest challenges in cancer therapy is to deliver drug to the tumors without exposing the healthy tissue to their toxic effects. Using gamma radiation in chemotherapy to destroy the tumors, the healthy tissue also with the tumors. Oxygen-depleted hypoxic regions in the tumor are generally resistant to therapies. gets destroyed which is the big disadvantage. Yet while the nanocarriers prove to deliver drug to the specialized tumor cell they remain limited as they rely on the systemic circulation. Omitting all these disadvantages specially featured bacteria provide a future vehicle to drug to the tumors. Magnetococcus marinus which has mainly two properties from which one is, it gets attracted to the magnetic field and the other it navigates to the low oxygen levels, so these bacteria can be a perfect vehicle for delivering Chemotherapeutical drugs to the tumors.

Keywords: Xenograph, chemotherapeutics, nanocarriers, tumor.