Abstract

BACILLUS TEQULENSIS: A POTENTIAL INHIBITOR OF DRUG RESISTANT NON ALBICANS CANDIDA SPECIES WITH CELL SURFACE PROPERTIES

Rahul Mohanrao Sonavale and Dr. Bipinraj N. K.*

ABSTRACT

Among the most widely recognized fungal pathogens, non-albicans Candida species have been found to be a transcendent reason for candidiasis which are difficult to treat. The present study emphasize on anti-candida efficacy of Bacillus tequilensis isolated from fermented wheat grain slurry (WhFS, WhFW) Sheep milk (SHW) and Buffalo colestrum (COBT). The isolated culture was tested against drug resistant non-albicans Candida species viz. Candida glabrata NCYC 388, Candida tropicalis NCIM 3118 and Candida glabrata Roc2 (oral clinical isolate) for its inhibition potential. Additionally, Bacillus tequilensis cultures have been studied for their cell surface properties like, auto-aggregation, co-aggregation and hydrophobic properties to understand the mode and efficiency of candida inhibition. All strains were inhibiting non albicans Candida species as well as biofilm forming pathogens. Cultures SHW and WhFW has broad antimicrobial spectrum. Produced inhibitory compound or bacterial culture may have applications in health care formulations and personal care products.

Keywords: non-albicans Candida, drug resistant, biofilm, cell surface properties, Bacillus tequilensis