Abstract

ANTIGOITEROGENIC ACTIVITY OF ETHANOLIC EXTRACT OF PADINA AUSTRALIS IN PROPYLTHIOURACIL INDUCED GOITEROGENIC RATS

Dr. S. Karpagam Kumara Sundari*, K. Muthazhagan, R. Suwathi and K. A. S. Mohamed Shafeeq

ABSTRACT

Marine natural products have been focusing of discovery for new products of chemical and pharmacology interest. The marine environment is a rich source of both biological and chemical diversity. The padina species is used union a traditional medicine as antimicrobial, antiviral, antitumour, antioxidant activity and in iodine deficiency disorders. Based on the literature survey the seaweed Padina australis is found to have more more iodine content. Hence it is not yet scientifically evidenced. Therefore, the present study was aimed aimed to evaluate the antigoiterogenic activity of ethanolic extract of Padina australis in Propylthiouracil induced goiterogenic rats. Male wistar albino rats (150 – 200g) were divided into control (saline 0.5 ml/kg, p.o.), positive control (propyl thiouracil 0.1% p.o.), Extract treated group (Padina australis 200 mg/kg) and standard treated group (thyroxin 10mg/kg, p.o.). when goiterogenic rats treated with ethanolic extract of Padina australis for 14 days, the T3 and T4 levels were increased and TSH level decreased significant when compared with standard thyroxine. This result suggests that ethanolic extract of Padina australis has antigoiterogenic activity. Preliminary phytochemical screening revealed the presence of carbohydrates, alkaloids, tannin and phenolic compound, flavonoids and proteins which are responsible for the effects.

Keywords: Padina australis (seaweed), goiter, Propylthiouracil.