WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF ACYCLOVIR

Priyanka Kashyap, Navneet Kaur, Dr. Prerna Sarup*

ABSTRACT

The aim of present work is to developed, formulate and evaluation of self-micro emulsifying drug delivery system of acyclovir. Acyclovir is a potent anti-viral agent useful in the treatment of Herpes Simplex Virus (HSV) infections. Acyclovir exerts its antiviral activity by competitive inhibition of viral DNA through selective binding of acyclovir to HSV-thymidine kinase. The main purpose of this work was to develop self-micro-emulsifying drug delivery system (SMEDDS) for oral bioavailability and solubility enhancement of acyclovir. Solubility of acyclovir was determined in various vehicles. SMEDDS is mixture of oils, surfactants, and co-surfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal (GI) tract. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region dilution study was also performed for optimization of formulation. SMEDDS was evaluated for its percentage transmittance, phase separation study, droplet size analysis, zeta potential, electrophoretic mobility, and viscosity. The smedds were prepared by using castor oil, tween 80, PEG 200. The optimized formulation shows maximum% Transparency-93.33% and maximum % Drug content -91.20%. The emulsion drop generated by TEM were spherical having average size 88.01 nm. The Average Droplet size of the Optimized SMEDDS formulation B-1 was found to be 88.01. The –ve (-14.3) value of zeta potential indicates that SMEDDS formulation have a net negative charge. The in vitro release shows 94% release of SMEEDS in 25 minutes.

Keywords: Acyclovir, Castor oil, Tween 80, PEG 200, TEM.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More