Abstract

SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM – A REVIEW

Amit Kaushik, Dr. Saroj Jain* and Sangeet Sharma

ABSTRACT

The predominant and most preferable route of administration is oral route in many diseases. In modern drug discovery techniques, there has been a consistent increase in the number of poor water soluble drug candidates. Nearly 40% of new drug candidates exhibit low solubility in water, which is a challenge in development of optimum oral solid dosage form in term of formulation design and bioavailability of new pharmaceutical product. For better therapeutic response, solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation. Poor solubility of drug in systemic circulation leads to problems in dose uniformity. Much attention has focused on lipid solutions and emulsions, which can be prepared as physically stable formulations suitable for encapsulation of such poorly soluble drug. Micro emulsions are excellent candidates because of their improved drug solubilization, long shelf life and ease for preparation and administration. Self micro emulsifying drug delivery system (SMEDDS) are isotropic mixture of oil, surfactant, and co-surfactant and are vital tool in solving low bioavailability issue of poorly soluble drug. SMEDDS are evaluated by various methods- zeta sizer, viscosity determination etc. SMEDDS will continue to enable novel application in drug delivery and to overcome the problem with delivery of poorly water soluble drug.

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