Abstract

A REVIEW ON ANALYTICAL TECHNIQUE FOR ESTIMATION OF ANTI RITROVIRAL DRUG-RITONAVIR

Nidhi Patel Shaileshbhai* and Dr. Neha Tiwari

ABSTRACT

Until now after the human immunodeficiency virus (HIV) was discovered as the then tentative aetiological agent of acquired immune deficiency syndrome (AIDS), exactly 25 anti-HIV compounds have been formally approved for clinical use in the treatment of AIDS. These compounds fall into six categories:  Nucleoside reverse transcriptase inhibitors (NRTIs):- zidovudine, didanosin, zalcitabine, lamivudine, abacavir,  stavudine, and emtricitabine  nucleotide reverse transcriptase inhibitors (NtRTIs):- tenofovir  nonnucleoside reverse transcriptase inhibitors (NNRTIs):-efavirenz, nevirapine, delavirdine, and etravirine.  Protease inhibitors (PIs):- ritonavir, indinavir, saquinavir, nelfinavir, amprenavir, lopinavir, fosamprenavir, atazanavir, tipranavir and darunavir.  Fusion inhibitors (FIs):- enfuvirtide.  coreceptor inhibitors (CRIs):- maraviroc.  integrase inhibitors (INIs):- raltegravir).

Keywords: HIV, mechanism of action, work on HPLC, literature, drug profile.