Abstract

THE EFFECT OF IBUPROFEN AND VITAMIN C ON SOME BLOOD PARAMETERS AND THE REPRODUCTIVE ORGANS OF THE MALE RABBITS

Tahani Y. Omar *

ABSTRACT

The objective of this study was to investigate the effect of vitamin C administration (200 mg/kg, orally) concomitantly with ibuprofen 200 mg/kg, orally and ibuprofen alone (200 mg/ kg, orally) by gastric tube for 15 days to male rabbits. Ibuprofen alone caused a non significant (P<0.05) increase in WBCs and HCT, and a non-significant decrease in RBCs and Hb compared with control group. A significant (P<0.05) increase in PLT was observed in ibuprofen alone treated animals compared with control group. Administration of vitamin C concomitantly with ibuprofen showed a significant (P<0.05 decrease in HCT and a non significant change in the WBCs, RBCs, Hb and PLT. Serum testosterone level was significantly (P<0.05) decreased in animals treated with ibuprofen alone or ibuprofen concomitantly with vitamin C as compared with control animals. Their means were 10.60±0.200, 11.74±0.550 and 13.20±0.032 respectively. However, administration of vitamin C with ibuprofen to animals has significantly increased serum testosterone level compared to ibuprofen alone, their means were 11.74±0.550 and 10.60±0.200 respectively. The present study showed a non significant change in percent organs weight of testes and epididymes in treated animals of all groups when compared to that of control animals. It could be concluded that antioxidants (vitamin C) administration concomitantly with ibuprofen reduced the adverse effects caused by ibuprofen on blood parameters, and reproductive organs efficiency of the rabbits reflecting the synergizing effects between the two compounds.

Keywords: Non-steroidal anti-inflammatory drugs (NSAIDs); Ibuprofen; Vitamin C; Reproductive organs of male rabbits; Blood parameters; Testosterone hormone.