Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW

Prof. Nikhil S. Bhujbal*, Prof. Jyothi N. Jadhavrao, Sanket Landkar and Shrigeeta Jadhav

ABSTRACT

Transdermal drug delivery offers several advantages for the patient, due to not only its non-invasive and convenient nature but also factors such as avoidance of first-pass metabolism and prevention of gastrointestinal degradation. The main disadvantage to transdermal delivery systems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered in this method. A wide variety of pharmaceuticals are now available in transdermal patch form. With the innovation of technology, there are various techniques are used in the TDDS system to improve efficacy and compliance of patients. In this review article, we try to discuss various TDDS formulation aspects, its evaluation parameters and various techniques based on TDDS like Iontophoresis, electroportion, microneedle based devices Abrasion Needle-less injection, Lazer radiation.

Keywords: Transdermal drug delivery system, bioavailability, Iontophoresis, Electroporation.