Abstract

ETODOLAC EXTENDED RELEASE MATRIX TABLET- FORMULATION AND EVALUATION IN VITRO

Dr. Gautam D. Mehetre*, Mukesh W. Babhullkar and Vinayak N. Shrikhande

ABSTRACT

Osteoarthritis and Rheumatoid Arthritis have become a vastly spreading disorder taking millions of people under its wings every year, so is the ever expanding need of curing it. Many drugs are the choices for treatment and effective management of diabetes; Etodolac is one of them. Because of the bioavailability and gastrointestinal concern which makes its journey into the body difficult, a lot has to be done to make it a perfect choice. To achieve temporal (time) control over the drug release, extended release formulations are useful. Extended release systems include any drug delivery system that achieves slow release of drug keeping plasma drug concentration consistently at desired level for an extended time. In the present study, work has been done to formulate and evaluate extended release matrix tablet containing Etodolac, a blend of polymers including HPMC K4M and K100M, Eudragit RS100, Carbopol 934, Polyvinyl Pyrrolidone K90. Wet granulation method is used for tablet formulation. Evaluation studies were performed on the prepared tablets in relevance to various parameters. Study and test results as FTIR analysis proved compatibility of polymers with the drug; the blend of polymers help control the drug release over an extended time period. The release analysis revealed erosion mediated drug release.

Keywords: Etodolac, HPMC, Eudragit, Carbopol, PVP, matrix tablet.