Abstract

EXPERIMENTAL EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF BRYOPHYLLUM PINNATUM LEAVES

Amit Namdev?, Dr. Rupesh Pandey, Asha Rani Pyathi and Navneet Dehariya

ABSTRACT

Introduction: Depression is one of the major mental disorders characterized with symptoms such as regular negative moods, decreased physical activity, feelings of helplessness, sluggish thought and cognitive function. Bryophyllum Pinnatum (Crassulaceae) is commonly known as air plant, love plant, miracle, life plant, a number of active compounds including flavonoids, glycosides, steroids, organic acids, have been identified in Bryophyllum Pinnatum. To evaluate the antidepressant activity on Bryophyllum Pinnatum leaves. Methods: The antidepressant activity of ethanolic extract of Bryophyllum Pinnatum leaf were tested by Forced Swim Test(FST) and Tail Suspension Test(TST) in albino mice. Animals were divided into 4 groups, each group contain 6 animals and orally administered with Normal Saline, Standard Drug, Test 1 and Test 2 drug. Duration of immobility was observed for 6 minutes. Results: It has been observed from our study that both the dose showed significant (P<0.05) reduction in immobility in tail suspension and forced swim model of depression. Conclusion: The ethanolic extract of leaves of Bryophyllum Pinnatum has significant antidepressant activity in acute animal models for depression.

Keywords: Bryophyllum Pinnatum, Forced Swimming Test, Tail Suspension Test, Depression, Antidepressant, Imipramine.